CD3 Epsilon Recombinant Protein
Product Specifications
Background
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
CAS Number
9000-83-3
NCBI Gene ID
102133065
Swiss Prot
Q95LI5
Accession Number
Q95LI5.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology, Neuroscience, Signal Transduction, Stem Cell, Other
Purity
>97% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
11.7 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
CD3e molecule, epsilon (CD3-TCR complex)
NCBI Organism
Macaca fascicularis
Background Reference 01
Gold DP, et al., 1986, Nature 321 (6068) : 431–4.
Background Reference 02
Clevers HC, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (21) : 8156–60.
Background Reference 03
De Saint Basile G, et al., 2004, J. Clin. Invest. 114 (10) : 1512–7.
Background Reference 04
Wong S, et al., 1991, Clin. Exp. Immunol. 83 (1) : 69–73.
Other Product Names
T3E, TCRE, CD3E, CD3-epsilon
Tested Applications
WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized
Curated Selection
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