PROTAC sEH-degrader-1
SEH-degrader-1 (Compound 8) serves as an inhibitor for sEH, with IC50 values of 3.8 nM and 210 nM against hsEH and msEH respectively. sEH-degrader-1 can effectively degrade sEH in mouse liver and brown adipose tissue (Red: UC-1728 , black: linker (HY-W248248), Blue: Thalidomide-5-piperazine (HY-W834174) ).
Product Specifications
UNSPSC
12352005
Target
Epoxide Hydrolase; PROTACs
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/protac-seh-degrader-1.html
Smiles
O=C(CCCCCCCCNC(C1=CC=C(O[C@@H]2CC[C@@H](NC(NC3=CC=C(OC(F)(F)F)C=C3)=O)CC2)C=C1)=O)N4CCC(CN(CC5)CCN5C6=CC7=C(C(N(C7=O)C(C(N8)=O)CCC8=O)=O)C=C6)CC4
Molecular Formula
C53H65F3N8O9
Molecular Weight
1015.13
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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