CD278 [ICOS] Recombinant Protein
Product Specifications
Background
CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
CAS Number
9000-83-3
NCBI Gene ID
54167
Swiss Prot
P22301
Accession Number
NP_059508
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Immunology
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Inducible T cell co-stimulator
NCBI Organism
Mus musculus
Other Product Names
ICOS, Inducible T Cell Costimulator, CRP1, CD28-related Protein-1, AILIM
Species
Mouse
Protein ID
224809335
Physical Properties
Lyophilized
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