CD209 / DC-SIGN Recombinant Protein
Product Specifications
Background
CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen. Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
NCBI Gene ID
30835
Swiss Prot
Q9NNX6
Accession Number
NP_066978.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology, Signal Transduction
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-250
Calculated Molecular Weight
41.3 kDa
Applications Notes
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 41.3 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
CD209molecule
NCBI Organism
Homo sapiens
Background Reference 01
Geijtenbeek TB, et al. 2000. Nat Immunol. 1 (4) :353-7.
Background Reference 02
Geijtenbeek TB, et al. 2000. Cell. 100 (5) :587-97.
Background Reference 03
Engering A, et al. 2002. J Immunol. 168 (5) :2118-26.
Other Product Names
DC-SIGN, CD209, DC-SIGN1, CLEC4L
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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