CD200 Recombinant Protein
Product Specifications
Background
CD200 is a transmembrane immunoregulatory protein that belongs to the immunoglobulin superfamily. It contains one Ig like V type domain and one Ig like C2 type domain in its extracelluar domain. CD200 is widely but not ubiquitously expressed. Its receptor (CD200R) is restricted primarily to mast cells, basophils, macrophages, and dendritic cells, which suggests myeloid cell regulation as the major function of CD200. CD200 and CD200R associate via their respective N-terminal Ig-like domains. In myeloid cells, CD200R initiates inhibitory signals following receptor-ligand contact. In T cells, CD200 functions as a co-stimulatory molecule independent of the CD28 pathway. In addition, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
NCBI Gene ID
4345
Swiss Prot
P41217
Accession Number
P41217
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-291
Calculated Molecular Weight
23.48 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
CD200 molecule
NCBI Organism
Homo sapiens
Other Product Names
OX-2 Membrane Glycoprotein, CD200, MOX1, MOX2, OX-2
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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