MCAM Recombinant Protein
Product Specifications
Background
CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle. CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
NCBI Gene ID
4162
Swiss Prot
P43121
Accession Number
NP_006491.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Immunology, Signal Transduction, Other
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-125
Calculated Molecular Weight
61.3 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Melanoma cell adhesion molecule
NCBI Organism
Homo sapiens
Background Reference 01
Kuske MD, et al.,1999, Cytogenet. Cell Genet. 87 (3-4) : 258.
Background Reference 02
Elshal MF, et al., 2005, Blood. 106 (8) : 2923–4.
Background Reference 03
Elshal MF, et al., 2007, BMC Immunol. 8: 29.
Background Reference 04
Covas DT, et al., 2008, Exp. Hematol. 36 (5) : 642–54.
Other Product Names
MCAM, CD146, MUC18
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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