CD58 Recombinant Protein
Product Specifications
Background
CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3) . CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
CAS Number
9000-83-3
NCBI Gene ID
965
Swiss Prot
P19256
Accession Number
AAH05930
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Other
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
22.3 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
CD58 molecule
NCBI Organism
Homo sapiens
Background Reference 01
Barbosa JA., et al., 1986, J. Immunol. 136 (8) : 3085–91.
Background Reference 02
Wang JH., et al., 1999, Cell 97 (6) : 791–803.
Background Reference 03
De Jager PL., et al., 2009, Proc Natl Acad Sci U S A. 106 (13) : 5264–9.
Other Product Names
CD58, LFA3, Ag3
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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