CCL4 Recombinant Protein
Product Specifications
Background
CCL4, (C-C motif chemokine 4; macrophage inflammatory protein 1beta) is a chemokine secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells and pulmonary smooth cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to pathologic inflammation, such as allergic asthma and ischemic myocardium. Full-length and truncated CCL4 exert biological activity through the receptor CCR5. The truncated form of CCL4 interacts additionally with CCR1 and CCR2b. The ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV. Both CCL4 forms block HIV-1 infection of T cells by inducing the downregulation of CCR5.
NCBI Gene ID
6351
Swiss Prot
Q9BQ51
Accession Number
AAI04227
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Chemokines & Cytokines, Immunology
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μ l sterile water. Add 1X PBS to the desired protein concentration.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-381
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Chemokine (C-C motif) ligand 4
NCBI Organism
Homo sapiens
Other Product Names
C-C Motif Chemokine 4, Lymphocyte Activation Gene 1 Protein, LAG-1, Macrophage Inflammatory Protein 1beta, MIP-1beta, T Cell Activation Protein 2, ACT-2, Small-inducible Cytokine A4, PAT 744, Protein H400
Species
Human
Protein ID
74353782
Physical Properties
Lyophilized
CAS Number
9000-83-3
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