CCL4 Recombinant Protein

Product Specifications

Background

CCL4, (C-C motif chemokine 4; macrophage inflammatory protein 1beta) is a chemokine secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells and pulmonary smooth cells. CCL4 attracts a variety of immune cells to sites of microbial infection as well as to pathologic inflammation, such as allergic asthma and ischemic myocardium. Full-length and truncated CCL4 exert biological activity through the receptor CCR5. The truncated form of CCL4 interacts additionally with CCR1 and CCR2b. The ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV. Both CCL4 forms block HIV-1 infection of T cells by inducing the downregulation of CCR5.

CAS Number

9000-83-3

NCBI Gene ID

6351

Swiss Prot

Q9BQ51

Accession Number

AAI04227

Tag

Fc Tag

Type

Recombinant Proteins

Source

CHO cells

Field of Research

Chemokines & Cytokines, Immunology

Buffer

Lyophilized from 0.2um-filtered solution in PBS. Reconstitute in 50 μ l sterile water. Add 1X PBS to the desired protein concentration.

Shipping Conditions

Room Temp

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

Applications Notes

This recombinant proteins is for research use only.

NCBI Official Name

Chemokine (C-C motif) ligand 4

NCBI Organism

Homo sapiens

Other Product Names

C-C Motif Chemokine 4, Lymphocyte Activation Gene 1 Protein, LAG-1, Macrophage Inflammatory Protein 1beta, MIP-1beta, T Cell Activation Protein 2, ACT-2, Small-inducible Cytokine A4, PAT 744, Protein H400