BMP Receptor II Recombinant Protein

Product Specifications

Background

Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.

CAS Number

9000-83-3

NCBI Gene ID

659

Swiss Prot

Q13873

Accession Number

Q13873

Tag

C-Fc-6 His tag

Type

Recombinant Proteins

Source

Human Cells

Field of Research

Signal Transduction, Other

Buffer

Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Shipping Conditions

Room Temp

Calculated Molecular Weight

41.9 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Bone morphogenetic protein receptor type II

NCBI Organism

Homo sapiens

Other Product Names

Bone Morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-2, Bone Morphogenetic Protein Receptor Type II, BMP Type II Receptor, BMPR-II, BMPR2, PPH1