BMP Receptor II Recombinant Protein
Product Specifications
Background
Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.
NCBI Gene ID
659
Swiss Prot
Q13873
Accession Number
Q13873
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Signal Transduction, Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-283
Calculated Molecular Weight
15.05 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Bone morphogenetic protein receptor type II
NCBI Organism
Homo sapiens
Other Product Names
Bone Morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-2, Bone Morphogenetic Protein Receptor Type II, BMP Type II Receptor, BMPR-II, BMPR2, PPH1
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
