HES1 Recombinant Protein
Product Specifications
Background
BHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.
NCBI Gene ID
3280
Swiss Prot
P43489
Accession Number
Q14469
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Other
Purity
>90% (SDS-PAGE)
Buffer
0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
Shipping Conditions
Blue Ice
Storage Conditions
Working aliquots are stable for up to 3 months when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-193
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Hes family bHLH transcription factor 1
NCBI Organism
Homo sapiens
Other Product Names
Hairy and Enhancer of Split 1, Transcription Factor HES-1, Class B Basic Helix-loop-helix Protein 39, bHLHb39, Hairy Homolog, Hairy-like Protein, HRY, hHL
Species
Human
Protein ID
5031763
Physical Properties
Liquid
CAS Number
9000-83-3
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1105445 Inquire
Recombinant Roseiflexus sp. ATP synthase subunit alpha (atpA), partial
Ask
View Details 