HES1 Recombinant Protein

Product Specifications

Background

BHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.

CAS Number

9000-83-3

NCBI Gene ID

3280

Swiss Prot

Q9NZH6

Accession Number

Q14469

Tag

His Tag

Type

Recombinant Proteins

Source

E. coli

Field of Research

Other

Purity

>90% (SDS-PAGE)

Buffer

0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.

Shipping Conditions

Blue Ice

Storage Conditions

Working aliquots are stable for up to 3 months when stored at -20˚ C.

Applications Notes

This recombinant proteins is for research use only.

NCBI Official Name

Hes family bHLH transcription factor 1

NCBI Organism

Homo sapiens

Other Product Names

Hairy and Enhancer of Split 1, Transcription Factor HES-1, Class B Basic Helix-loop-helix Protein 39, bHLHb39, Hairy Homolog, Hairy-like Protein, HRY, hHL