Betatrophin Recombinant Protein
Product Specifications
Background
Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8) ) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
NCBI Gene ID
55908
Swiss Prot
Q8N5Z0
Accession Number
Q6UXH0
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Obesity
Concentration
0.1mg/ml after reconstitution.
Buffer
Contains PBS + 0.02% CHAPS. Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-325
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Chromosome 19 open reading frame 80
NCBI Organism
Homo sapiens
Other Product Names
Angiopoietin-like Protein 8, ANGPTL8, Lipasin, Refeeding-induced Fat and Liver Protein, RIFL
Species
Human
Protein ID
291219911
Physical Properties
Lyophilized
CAS Number
9000-83-3
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