Betatrophin Recombinant Protein
Product Specifications
Background
Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8) ) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
NCBI Gene ID
624219
Swiss Prot
Q9HAN9
Accession Number
Q8R1L8
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Concentration
0.1mg/ml after reconstitution.
Buffer
Contains PBS + 0.02% CHAPS. Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-322
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Angiopoietin-like 8
NCBI Organism
Mus musculus
Other Product Names
Angiopoietin-like Protein 8, ANGPTL8, Lipasin, Refeeding-induced Fat and Liver Protein, RIFL
Species
Mouse
Protein ID
172045807
Physical Properties
Lyophilized
CAS Number
9000-83-3
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