BCL2L1 Recombinant Protein
Product Specifications
Background
Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL) . BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
NCBI Gene ID
598
Swiss Prot
Q07817
Accession Number
AAH19307
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Apoptosis, Cancer
Purity
>92% as determined by SDS-PAGE.
Buffer
20mM HEPES, 50mM KCl, pH 7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-056
Calculated Molecular Weight
24.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
BCL2-like 1
NCBI Organism
Homo sapiens
Background Reference 01
Terrano D.T., et al., 2010, Mol. Cell. Biol. 30:640-656.
Background Reference 02
Wang J., et al., 2011, Cell. Signal. 23:2030-2038.
Other Product Names
BCL2L1, Bcl-XL, Bcl2-L-1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, bcl-xS
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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