BCL2L1 Recombinant Protein
Product Specifications
Background
Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL) . BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
CAS Number
9000-83-3
NCBI Gene ID
598
Swiss Prot
Q07817
Accession Number
AAH19307
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Apoptosis, Cancer
Purity
>92% as determined by SDS-PAGE.
Buffer
20mM HEPES, 50mM KCl, pH 7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
24.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
BCL2-like 1
NCBI Organism
Homo sapiens
Background Reference 01
Terrano D.T., et al., 2010, Mol. Cell. Biol. 30:640-656.
Background Reference 02
Wang J., et al., 2011, Cell. Signal. 23:2030-2038.
Other Product Names
BCL2L1, Bcl-XL, Bcl2-L-1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, bcl-xS
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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