BAFFR Recombinant Protein
Product Specifications
Background
BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE) . Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
CAS Number
9000-83-3
NCBI Gene ID
72049
Swiss Prot
Q9D8D0
Accession Number
NP_082351.1
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Other
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
33.3 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
Tumor necrosis factor receptor superfamily member 13C
NCBI Organism
Mus musculus
Background Reference 01
Thompson JS., et al.,2001, Science, 293 (5537) : 2108-2111.
Background Reference 02
Mbrose CM., 2003, Journal of Biological Regulators and Homeostatic Agents, 16 (3) : 211-213.
Background Reference 03
Treml LS., et al., 2006, Seminars in Immunology, 18 (5) : 297-304.
Other Product Names
BAFFR, TNFRSF13C, BAFF-R, BROMIX, CD268, CVID4, prolixin
Tested Applications
ELISA, WB
Species
Mouse
Physical Properties
Lyophilized
Curated Selection
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