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B7-H7 / HHLA2 Recombinant Protein

Product Specifications

Background

B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.

NCBI Gene ID

11148

Swiss Prot

Q9UM44

Accession Number

NP_009003.1

Tag

Fc Tag

Type

Recombinant Proteins

Source

HEK293 cells

Field of Research

Immunology

Purity

>90% as determined by reduced SDS-PAGE.

Buffer

Tris with Glycine, Arginine and NaCl, pH7.5

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=11-382

Calculated Molecular Weight

63.4 kDa

Applications Notes

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.4 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

NCBI Official Name

HERV-H LTR-associating 2

NCBI Organism

Homo sapiens

Background Reference 01

Ni L., et al., 2017, Mol. Cancer. Ther. 16:1203-1211.

Background Reference 02

Jung K., et al., 2013, Immune. Netw. 13:184-193.

Background Reference 03

Janakiram M., et al., 2015, Clin. Cancer. Res. 21:2359-2366.

Other Product Names

B7-H7, HHLA2, B7 Homolog 7

Tested Applications

ELISA, WB

Species

Human

Physical Properties

Lyophilized

CAS Number

9000-83-3

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