B7-H7 / HHLA2 Recombinant Protein
Product Specifications
Background
B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.
NCBI Gene ID
11148
Swiss Prot
Q9UM44
Accession Number
NP_009003.1
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>90% as determined by reduced SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-382
Calculated Molecular Weight
63.4 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.4 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
HERV-H LTR-associating 2
NCBI Organism
Homo sapiens
Background Reference 01
Ni L., et al., 2017, Mol. Cancer. Ther. 16:1203-1211.
Background Reference 02
Jung K., et al., 2013, Immune. Netw. 13:184-193.
Background Reference 03
Janakiram M., et al., 2015, Clin. Cancer. Res. 21:2359-2366.
Other Product Names
B7-H7, HHLA2, B7 Homolog 7
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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