B7-H4 Recombinant Protein

Product Specifications

Background

B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs) . In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.

CAS Number

9000-83-3

NCBI Gene ID

242122

Swiss Prot

P09793

Accession Number

NP_848709

Tag

Fc Tag

Type

Recombinant Proteins

Source

CHO cells

Field of Research

Immunology

Buffer

Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μ l sterile water. Add 1X PBS to the desired protein concentration.

Shipping Conditions

Room Temp

Storage Conditions

Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.

Applications Notes

This recombinant proteins is for research use only.

NCBI Official Name

V-set domain containing T cell activation inhibitor 1

NCBI Organism

Mus musculus

Other Product Names

V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1