B7-H4 Recombinant Protein
Product Specifications
Background
B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting of T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs) . In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumor cancer cells. The role of B7-H4 in tumor progression may be to transform precancerous cells and then protect them from immunosurveillance.
CAS Number
9000-83-3
NCBI Gene ID
79679
Swiss Prot
P16410
Accession Number
NP_078902
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Cancer, Innate Immunity
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μ l sterile water. Add 1X PBS to the desired protein concentration.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-370
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
V-set domain containing T cell activation inhibitor 1
NCBI Organism
Homo sapiens
Other Product Names
V-set Domain-containing T Cell Activation Inhibitor 1, VTCN1, B7h.5, Immune Costimulatory Protein B7-H4, T Cell Costimulatory Molecule B7x, Protein B7S1
Species
Human
Protein ID
99028881
Physical Properties
Lyophilized
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