B7-H3 Recombinant Protein
Product Specifications
Background
B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
NCBI Gene ID
80381
Swiss Prot
Q5ZPR3-2
Accession Number
Q5ZPR3-2
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-824
Calculated Molecular Weight
50 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
CD276 antigen
NCBI Organism
Homo sapiens
Background Reference 01
Chapoval A.I., et al., 2001, Nat. Immunol. 2:269-274.
Background Reference 02
Castriconi R., et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645.
Background Reference 03
Wang L., et al., 2005, Eur. J. Immunol. 35:428-438.
Other Product Names
B7-H3, CD276, B7 homolog 3
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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