B7-H3 / CD276 Recombinant Protein
Product Specifications
Background
B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
CAS Number
9000-83-3
NCBI Gene ID
102131295
Accession Number
XP_015308534.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-279
Calculated Molecular Weight
49.0 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.0 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
CD276molecule
NCBI Organism
Macaca fascicularis
Background Reference 01
Chapoval A.I., et al., 2001, Nat. Immunol. 2:269-274.
Background Reference 02
Castriconi R., et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645.
Background Reference 03
Wang L., et al., 2005, Eur. J. Immunol. 35:428-438.
Other Product Names
B7-H3, CD276, B7 homolog 3
Tested Applications
ELISA, WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized
Curated Selection
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