Vaccinia Virus B18R Recombinant Protein
Product Specifications
Background
B18R is a type I interferon (IFN) -binding protein and it is encoded by the B18R open reading frame in the WR (Western Reserve) strain of vaccinia virus, which contains two Ig-like C2-type domains and one Ig-like V-type domain. B18R exists in a soluble and a membrane-bound form. As a type I IFN receptor, B18R counteracts the antiviral effects of host IFN-alpha/beta. Also, B18R acts as a soluble IFN-alpha receptor and thus inhibits the interaction between host IFN-alpha and its receptor.
CAS Number
9000-83-3
NCBI Gene ID
3707577
Swiss Prot
P25213
Accession Number
P25213
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Infectious Disease
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
40.3 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Soluble interferon alpha/beta receptor B18
NCBI Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR) )
Background Reference 01
Alcami A., et al., 2000, J. Virol. 74:11230-11239.
Background Reference 02
Waibler Z., et al., 2009, J. Virol. 83:1563-1571.
Other Product Names
B18R
Tested Applications
ELISA, WB
Species
Vaccinia Virus
Physical Properties
Lyophilized
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