AXL Recombinant Protein
Product Specifications
Background
AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.
NCBI Gene ID
558
Swiss Prot
P30530
Accession Number
AAH32229
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Cell Cycle, Signal Transduction, Other
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH 7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-037
Calculated Molecular Weight
46.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
AXL receptor tyrosine kinase
NCBI Organism
Homo sapiens
Background Reference 01
Varnum B.C., et al., 1995, Nature 373:623-626.
Background Reference 02
Gallicchio M., et al., 2005, Blood 105:1970-1976.
Background Reference 03
Park I.K., et al., 2009, Blood 113:2470-2477.
Other Product Names
AXL, UFO
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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