Autotaxin Recombinant Protein
Product Specifications
Background
Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.
CAS Number
9000-83-3
NCBI Gene ID
5168
Swiss Prot
Q13822
Accession Number
NP_001035181
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Neuroscience, Obesity, Signal Transduction, Other
Purity
>92% as determined by SDS-PAGE.
Buffer
50 mM Tris, 150 mM NaCl, pH 7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
94.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Ectonucleotide pyrophosphatase/phosphodiesterase 2
NCBI Organism
Homo sapiens
Background Reference 01
Stracke M.L., et al., 1992, J. Biol. Chem. 267:2524-2529.
Background Reference 02
Nam S.W., et al., 2001, Cancer Res. 61:6938-6944.
Background Reference 03
Hausmann J., et al., 2011, Nat. Struct. Mol. Biol. 18:198-204.
Other Product Names
ENPP2, E-NPP 2, Autotaxin, LysoPLD, ATX, PDNP2, ATX-X, NPP2, PD-IALPHA
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
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