APE Recombinant Protein
Product Specifications
Background
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
CAS Number
9000-83-3
NCBI Gene ID
328
Swiss Prot
P27695
Accession Number
P27695
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Homeostasis, Other
Buffer
Supplied as a 0.2 um filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
35.62 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Apurinic/apyrimidinic endodeoxyribonuclease 1
NCBI Organism
Homo sapiens
Other Product Names
DNA- (Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-Apyrimidinic Endonuclease 1, AP Endonuclease 1, APE-1REF-1, Redox Factor-1, APEX1, APE, APE1, APEX, APX, HAP1, REF1
Species
Human
Physical Properties
Liquid
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