Human ACE2 Recombinant Protein
Product Specifications
Background
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Accession Number
NP_001358344.1 or Uniprot Q9BYF1
Tag
N-His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Infectious Disease
Purity
>90% as determined by SDS-PAGE quantitative densitometry by Coomassie Blue Staining.
Buffer
Supplied as lyophilized from PBS, pH 7.5, 0.02%NLS. Please reconstitute the protein with ddH2O to the concentration with 1mg/ml.
Shipping Conditions
Room Temp
Storage Conditions
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚ C for one week. Store at -20 to -80 ˚ C for twelve months from the date of receipt.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=10-430
Calculated Molecular Weight
42.71kDa
Applications Notes
Immunogen
Other Product Names
ACE-related carboxypeptidase, Angiotensin-converting enzyme homolog, Metalloprotease MPROT15
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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