Human ACE2 Recombinant Protein

Product Specifications

Background

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

CAS Number

9000-83-3

Accession Number

NP_001358344.1 or Uniprot Q9BYF1

Tag

N-His Tag

Type

Recombinant Proteins

Source

E. coli

Field of Research

Infectious Disease

Purity

>90% as determined by SDS-PAGE quantitative densitometry by Coomassie Blue Staining.

Buffer

Supplied as lyophilized from PBS, pH 7.5, 0.02%NLS. Please reconstitute the protein with ddH2O to the concentration with 1mg/ml.

Shipping Conditions

Room Temp

Storage Conditions

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚ C for one week. Store at -20 to -80 ˚ C for twelve months from the date of receipt.