ACE-2 Recombinant Protein
Product Specifications
Background
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
CAS Number
9000-83-3
NCBI Gene ID
70008
Swiss Prot
Q8R0I0
Accession Number
Q8R0I0
Tag
C-10 His tag
Type
Recombinant Proteins
Source
Mammalian Cells
Field of Research
Infectious Disease
Buffer
Supplied as a 0.2 um filtered solution of 25mM Tris-HCl, 150mM NaCl, 1mM ZnCl2, pH 7.5.
Shipping Conditions
Blue Ice
Storage Conditions
Store below -20˚ C, stable for 6 months after receipt.
Calculated Molecular Weight
84.9KDa
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Angiotensin-converting enzyme 2
NCBI Organism
Mus musculus
Other Product Names
Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Species
Mouse
Physical Properties
Liquid
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