ANGPTL4 (166-406) Recombinant Protein
Product Specifications
Background
Angiopoietin-related protein 4 (ANGPTL4) is also known as Hepatic fibrinogen / angiopoietin - related protein (HFARP), ARP4, PGAR. ANGPTL4 contains one fibrinogen C-terminal domain. ANGPTL4 is a homooligomer , and the homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix. ANGPTL4 may act as a regulator of angiogenesis and modulate tumorigenesis. ANGPTL4 inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action.
CAS Number
9000-83-3
NCBI Gene ID
51129
Swiss Prot
Q9BY76
Accession Number
NP_647475
Tag
N-His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Obesity, Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM MOPS, 100 mM NaCl, pH7.2 with 0.1% CHAPS
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
27.9 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Angiopoietin-like 4
NCBI Organism
Homo sapiens
Background Reference 01
Yoon J.C., et al., 2000, Mol. Cell. Biol. 20:5343-5349.
Background Reference 02
Ito Y., et al., 2003, Cancer Res. 63:6651-6657.
Background Reference 03
Zhu H., et al., 2002, Zhonghua Zhong Liu Za Zhi 24:123-125.
Other Product Names
ANGPTL4, ANGPTL2, ARP4, FIAF, HFARP, NL2, PGAR, pp1158, Angiopoietin like 4
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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