ANGPTL7 / CDT6 Recombinant Protein
Product Specifications
Background
Angiopoietin-like 7 (ANGPTL7) is also known as Corneal-Derived Transcript 6 (CDT6), and is a secreted glycoprotein that is structurally related to the angiopoietins. It is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated in glaucoma aqueous humor. Recently, ANGPTL proteins, including ANGPTL-2, -3, -4, -5 and -7, are identified as growth factors in combination with SCF, Thrombopoietin, IGF-II and FGF acidic that enhance the expansion and engraftment of human and mouse hematopoietic stem cells.
CAS Number
9000-83-3
NCBI Gene ID
10218
Swiss Prot
O43827
Accession Number
NP_066969.1
Tag
Mouse IgG Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Other
Purity
>90% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
64.1 kDa
Applications Notes
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 64.1 kDa. The protein migrates as 60 kDa and 76 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Angiopoietin like 7
NCBI Organism
Homo sapiens
Background Reference 01
Peek R., et al., 1998, Invest. Opthalmol. Visual Sci. 39 (10) : 1782-1788.
Background Reference 02
Peek R., et al., 2002, J. Biol. Chem. 277 (1) : 686-693.
Background Reference 03
Kuchtey, J. et al., 2008, Invest. Opthalmol. Visual Sci. 49 (8) : 3438-3448.
Other Product Names
ANGPTL7, CDT6
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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