Fetuin A Recombinant Protein
Product Specifications
Background
Alpha-2-HS-glycoprotein (AHSG) is also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A (FETUA), is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the cystatin family of proteases inhibitors and the fetuin class of plasma binding proteins. AHSG / Fetuin A is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Fetuins are carrier proteins like albumin. Fetuin-A / AHSG forms soluble complexes with calcium and phosphate and thus is a carrier of otherwise insoluble calcium phosphate. Thus AHSG / Fetuin A is a potent inhibitor of pathological calcification. Fetuin A / FETUA promotes phagocytosis of apoptotic cells and plays a role in bone development, calcium homeostasis and insulin sensitivity. Mice deficient in Fetuin-A show systemic calcification of soft tissues.
CAS Number
9000-83-3
NCBI Gene ID
197
Swiss Prot
P02765
Accession Number
NP_001613
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer, Cell Cycle, Immunology, Neuroscience, Obesity, Signal Transduction
Purity
>98% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
38.2 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Alpha-2-HS-glycoprotein
NCBI Organism
Homo sapiens
Background Reference 01
Jahnen-Dechent W., et al., 1994, Eur. J. Biochem. 226 : 59–69.
Background Reference 02
Lee C., et al., 2009, Frontiers in Bioscience 14: 2911–2922.
Background Reference 03
Heiss A., et al., 2008, J. Biol. Chem. 283 (21) : 14815–25.
Background Reference 04
Jahnen-Dechent W., et al., 2008, J. Mol. Med. 86 (4) : 379–89.
Other Product Names
AHSG, FETUA, Fetuin A
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
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