ALK-7 Recombinant Protein
Product Specifications
Background
ALK-7 (Activin receptor-like kinase 7) is also known as Activin receptor type-1C, ACTR-IC, ACVR1C. Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
CAS Number
9000-83-3
NCBI Gene ID
130399
Swiss Prot
Q8NER5
Accession Number
NP_660302.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
20 mM Tris, 150 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
11.9 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11.9 kDa. The protein migrates as 15-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
ActivinAreceptortype1C
NCBI Organism
Homo sapiens
Background Reference 01
Xu G, et al. 2004. J Clin Endocrinol Metab. 89 (11) :5523-34.
Background Reference 02
Bondestam J, et al. 2001. Cytogenet Cell Genet. 95 (3-4) :157-62.
Other Product Names
ALK-7, ACTR-IC, ACVR1C
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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