ASM-like phosphodiesterase 3a Recombinant Protein
Product Specifications
Background
Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A) is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.
NCBI Gene ID
10924
Swiss Prot
Q92484
Accession Number
Q92484
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Obesity, Signal Transduction
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-932
Calculated Molecular Weight
49.9 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Sphingomyelin phosphodiesterase acid like 3A
NCBI Organism
Homo sapiens
Other Product Names
Acid sphingomyelinase-like phosphodiesterase 3a, ASM-like phosphodiesterase 3a, SMPDL3A, ASML3A
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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