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ASM-like phosphodiesterase 3a Recombinant Protein

Product Specifications

Background

Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A) is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.

CAS Number

9000-83-3

NCBI Gene ID

10924

Swiss Prot

Q92484

Accession Number

Q92484

Tag

C-6 His tag

Type

Recombinant Proteins

Source

Human Cells

Field of Research

Obesity, Signal Transduction

Buffer

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Shipping Conditions

Room Temp

Calculated Molecular Weight

49.9 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Sphingomyelin phosphodiesterase acid like 3A

NCBI Organism

Homo sapiens

Other Product Names

Acid sphingomyelinase-like phosphodiesterase 3a, ASM-like phosphodiesterase 3a, SMPDL3A, ASML3A

Species

Human

Physical Properties

Lyophilized

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