15-PGDH Recombinant Protein
Product Specifications
Background
15-hydroxyprostaglandin dehydrogenase [NAD (+) ], also known as Prostaglandin dehydrogenase 1, 15-PGDH, HPGD and PGDH1, belongs to the short-chain dehydrogenases/reductases (SDR) family. HPGD localizes to the cytoplasm and can be found in colon epithelium, existing as a homodimer. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. HPGD is down-regulated by cortisol, dexamethasone and betamethasone, up-regulated by TGFB1. HPGD inhibits in vivo proliferation of colon cancer cells. HPGD is the key enzyme for the inactivation of prostaglandins, and thus regulates processes such as inflammation or proliferation.
CAS Number
9000-83-3
NCBI Gene ID
3248
Swiss Prot
P15428
Accession Number
P15428
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Immunology, Signal Transduction
Buffer
Supplied as a 0.2 um filtered solution of 20mM HEPES,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Calculated Molecular Weight
30 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Hydroxyprostaglandin dehydrogenase 15- (NAD)
NCBI Organism
Homo sapiens
Other Product Names
15-Hydroxyprostaglandin Dehydrogenase [NAD (+) ], 15-PGDH, Prostaglandin Dehydrogenase 1, HPGD, PGDH1
Species
Human
Protein ID
372626423
Physical Properties
Liquid
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