Edelinontrine
Edelinontrine (PF-04447943) is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM) .
Product Specifications
CAS Number
1082744-20-4
Product Name Alternative
PF-04447943
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/edelinontrine.html
Concentration
10mM
Purity
99.85
Solubility
DMSO : ≥ 54.6 mg/mL
Smiles
O=C1C2=C(N(C3CCOCC3)N=C2)N=C([C@@H]4CN(CC5=NC=CC=N5)C[C@H]4C)N1
Molecular Formula
C20H25N7O2
Molecular Weight
395.46
Precautions
H315, H319, H335
References & Citations
[1]Kleiman RJ, et al. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J Pharmacol Exp Ther. 2012 May;341 (2) :396-409.|[2]Hutson, P. H, et al. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[ (3S,4S) -4-methyl-1- (pyrimidin-2-ylmethyl) pyrrolidin-3-yl]-1- (tetrahydro-2H-pyran-4-yl) -1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE9
Available Sizes
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