Edelinontrine

Edelinontrine (PF-04447943) is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM) .

Product Specifications

CAS Number

[1082744-20-4]

Product Name Alternative

PF-04447943

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/edelinontrine.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : ≥ 54.6 mg/mL

Smiles

O=C1C2=C(N(C3CCOCC3)N=C2)N=C([C@@H]4CN(CC5=NC=CC=N5)C[C@H]4C)N1

Molecular Formula

C20H25N7O2

Molecular Weight

395.46

Precautions

H315, H319, H335

References & Citations

[1]Kleiman RJ, et al. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J Pharmacol Exp Ther. 2012 May;341 (2) :396-409.|[2]Hutson, P. H, et al. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[ (3S,4S) -4-methyl-1- (pyrimidin-2-ylmethyl) pyrrolidin-3-yl]-1- (tetrahydro-2H-pyran-4-yl) -1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and