SF 11
SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM) . Antidepressant-like activity[1][2].
Product Specifications
CAS Number
443292-81-7
UNSPSC
12352005
Hazard Statement
H319
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sf-11.html
Purity
99.15
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(C(NC4=CC=C(OCC)C=C4)=S)CC3
Molecular Formula
C27H30N2O2S
Molecular Weight
446.60
Precautions
H319
References & Citations
[1]Domin H, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019;10 (8) :3454-3463. |[2]Brothers SP, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol Pharmacol. 2010;77 (1) :46-57.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NPY Y2 receptor
Available Sizes
Frequently Asked Questions
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