SF 11

SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM) . Antidepressant-like activity[1][2].

Product Specifications

CAS Number

[443292-81-7]

UNSPSC

12352005

Hazard Statement

H319

Target

Neuropeptide Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sf-11.html

Purity

99.15

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(C(NC4=CC=C(OCC)C=C4)=S)CC3

Molecular Formula

C27H30N2O2S

Molecular Weight

446.60

Precautions

H319

References & Citations

[1]Domin H, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019;10 (8) :3454-3463. |[2]Brothers SP, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol Pharmacol. 2010;77 (1) :46-57.