7-Deaza-2′-deoxyguanosine 5′-triphosphate
7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, is a telomerase inhibitor (IC50: 11 μM) [1].
Product Specifications
CAS Number
[101515-08-6]
Product Name Alternative
7-Deaza-2'-dGTP
UNSPSC
12352005
Hazard Statement
H371
Target
Telomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/7-deaza-2-deoxyguanosine-5-triphosphate.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1C[C@H](N2C(N=C(N)NC3=O)=C3C=C2)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Molecular Formula
C11H17N4O13P3
Molecular Weight
506.19
Precautions
P260-P264-P270-P405-P501
References & Citations
[1]Fletcher TM, et al. Human telomerase inhibition by 7-deaza-2'-deoxypurine nucleoside triphosphates. Biochemistry. 1996 Dec 10;35 (49) :15611-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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