Azalamellarin N
Azalamellarin N is an inhibitor of pyroptosis and has different inhibitory effects on different pyroptosis inducers. Azalamellarin N inhibits pyroptosis by targeting molecules that act upstream of NLRP3 inflammasome activation, rather than directly targeting components of the NLRP3 inflammasome. Inhibitory potency against different pyroptosis inducers: Nigericin (HY-127019) > R837 (HY-B0180) [1].
Product Specifications
CAS Number
[1809535-57-6]
Product Name Alternative
AZL-N
UNSPSC
12352005
Target
Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/azalamellarin-n.html
Purity
99.58
Solubility
10 mM in DMSO
Smiles
OC1=CC(C2=C(C(C=C(OC)C(O)=C3)=C3C=C4)N4C5=C2C6=C(C=C(O)C(OC)=C6)NC5=O)=CC=C1OC
Molecular Formula
C28H22N2O7
Molecular Weight
498.48
References & Citations
[1]Takouda J, et al. Identification of Azalamellarin N as a Pyroptosis Inhibitor. Biol Pharm Bull. 2024;47 (1) :28-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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