Acetylcysteine

Acetylcysteine (N-Acetylcysteine) is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine is the most stable form of cysteine during drug delivery and can be used in disulfidptosis studies[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[616-91-1]

Product Name Alternative

N-Acetylcysteine; N-Acetyl-L-cysteine; NAC

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Disulfidptosis; Endogenous Metabolite; Ferroptosis; Influenza Virus; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Infection; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Acetylcysteine.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

SC[C@@H](C(O)=O)NC(C)=O

Molecular Formula

C5H9NO3S

Molecular Weight

163.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Halasi M, et al. ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors. Biochem J. 2013 Sep 1;454 (2) :201-8.|[2]Ferrari G, et al. N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci. 1995 Apr;15 (4) :2857-66.|[3]Tsai JC, et al. Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J Biol Chem. 1996 Feb 16;271 (7) :3667-70.|[4]Yan CY, et al. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci. 1998 Jun 1;18 (11) :4042-9.|[5]Farr SA, et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem. 2003 Mar;84 (5) :1173-83.|[6]Kalimeris K, et al. N-acetylcysteine ameliorates liver injury in a rat model of intestinal ischemia reperfusion. J Surg Res. 2016 Dec;206 (2) :263-272.|[7]Garigliany MM, et al. N-acetylcysteine lacks universal inhibitory activity against influenza A viruses. J Negat Results Biomed. 2011 May 9;10:5.|[8]Gu Q, et al. Disulfidptosis, a novel cell death pathway: molecular landscape and therapeutic implications[J]. Aging Dis, 2024, 10.