Elastase, Porcine pancreas

Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters[1][2][3].

Product Specifications

CAS Number

[39445-21-1]

Product Name Alternative

EC 3.4.21.36; Pancreatopeptidase E

UNSPSC

12352204

Hazard Statement

H302, H315, H319, H335

Target

Elastase

Type

Enzyme

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/elastase-porcine-pancreas.html

Solubility

H2O : ≥ 5 mg/mL|H2O : 50 mg/mL (ultrasonic; adjust pH to 9 with NaOH)

Smiles

[Elastase,Porcinepancreas]

Molecular Formula

C1135H1759N331O346S10

Molecular Weight

25898.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Shotton DM, et, al. Amino-acid sequence of porcine pancreatic elastase and its homologies with other serine proteinases. Nature. 1970 Feb 28;225 (5235) :802-6.|[2]Teshima T, et, al. A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates. J Biol Chem. 1982 May 10;257 (9) :5085-91.|[3]Stone PJ, et, al. Induction and exacerbation of emphysema in hamsters with human neutrophil elastase inactivated reversibly by a peptide boronic acid. Am Rev Respir Dis. 1990 Jan;141 (1) :47-52.