3-Methyltoxoflavin
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM.
Product Specifications
CAS Number
[32502-62-8]
UNSPSC
12352005
Hazard Statement
H300
Target
PDI
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-Methyltoxoflavin.html
Purity
98.62
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=NN(C)C(C2=N1)=NC(N(C)C2=O)=O
Molecular Formula
C8H9N5O2
Molecular Weight
207.19
Precautions
H300
References & Citations
[1]Kyani A, et al. Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma. ChemMedChem. 2018 Jan 22;13 (2) :164-177.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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