Velaresol

Velaresol (BW 12C) is a potent left-shifting anti-sickling compound in vitro[1]. Sickle cell disease is an inherited disorder of the hemoglobin molecule. When hemoglobin molecules are exposed to a variety of environments, the red blood cell hemoglobin polymerizes, twists, and morphs into a sickle shape.

Product Specifications

CAS Number

[77858-21-0]

Product Name Alternative

BW 12C; 12C79; BW 12C79

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/velaresol.html

Purity

99.59

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(CCCCOC1=C(C(O)=CC=C1)C=O)=O

Molecular Formula

C12H14O5

Molecular Weight

238.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Fitzharris P, et al. The effects in volunteers of BW12C, a compound designed to left-shift the blood-oxygen saturation curve. Br J Clin Pharmacol. 1985 Apr;19 (4) :471-81.