N-Formyl-L-histidine

N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM[1][2].

Product Specifications

CAS Number

[15191-21-6]

Product Name Alternative

Formyl-L-histidine

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

Aminoacyl-tRNA Synthetase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-formyl-l-histidine.html

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@@H](NC=O)CC1=CN=CN1

Molecular Formula

C7H9N3O3

Molecular Weight

183.16

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Lepore GC, et al. Histidyl-tRNA synthetase from Salmonella typhimurium: specificity in the binding of histidine analogues. Eur J Biochem. 1975 Aug 15;56 (2) :369-74.|[2]Shibatani T, et al. Crystalline L-histidine ammonia-lyase of Achromobacter liquidum. Crystallization and enzymic properties. Eur J Biochem. 1975 Jun 16;55 (1) :263-9.