Biotin-YVAD-FMK
Biotin-YVAD-FMK is an inhibitor for vacuolar processing enzyme (VPE), with a 64% inhibition at 5 μM. Biotin-YVAD-FMK is an irreversible substrate for caspase 1[1][2].
Product Specifications
UNSPSC
12352209
Target
Caspase
Type
Peptides
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/biotin-yvad-fmk.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC(CCCC[C@@H]1SC[C@]([H])(N2)[C@@]1(NC2=O)[H])=O)CC3=CC=C(O)C=C3)N[C@H](C(N[C@H](C(N[C@H](C(CF)=O)CC(O)=O)=O)C)=O)C(C)C
Molecular Formula
C32H45FN6O9S
Molecular Weight
708.80
References & Citations
[1]Hatsugai N, et al., A plant vacuolar protease, VPE, mediates virus-induced hypersensitive cell death. Science. 2004 Aug 6;305 (5685) :855-8. |[2]Case CL, et al., Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila. mBio. 2011 Sep 1;2 (4) :e00117-11.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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