Allopurinol riboside
Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.
Product Specifications
CAS Number
16220-07-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite; Endogenous Metabolite; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Allopurinol_riboside.html
Concentration
10mM
Purity
99.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C=NN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)=C2N=CN1
Molecular Formula
C10H12N4O5
Molecular Weight
268.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Nishida Y, et al. Inhibition of purine nucleoside phosphorylase activity and of T-cell function with allopurinol-riboside. Agents Actions. 1979 Dec;9 (5-6) :549-52.|[2]Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58 (1) :87-114.|[3]Shapiro TA, et al. Pharmacokinetics and metabolism of allopurinol riboside. Clin Pharmacol Ther. 1991 May;49 (5) :506-14.|[4]Were JB, et al. Effects of probenecid on the pharmacokinetics of allopurinol riboside. Antimicrob Agents Chemother. 1993 May;37 (5) :1193-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Leishmania
Available Sizes
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