Allopurinol riboside

Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

Product Specifications

CAS Number

[16220-07-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; Endogenous Metabolite; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Allopurinol_riboside.html

Concentration

10mM

Purity

99.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(C=NN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)=C2N=CN1

Molecular Formula

C10H12N4O5

Molecular Weight

268.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Nishida Y, et al. Inhibition of purine nucleoside phosphorylase activity and of T-cell function with allopurinol-riboside. Agents Actions. 1979 Dec;9 (5-6) :549-52.|[2]Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58 (1) :87-114.|[3]Shapiro TA, et al. Pharmacokinetics and metabolism of allopurinol riboside. Clin Pharmacol Ther. 1991 May;49 (5) :506-14.|[4]Were JB, et al. Effects of probenecid on the pharmacokinetics of allopurinol riboside. Antimicrob Agents Chemother. 1993 May;37 (5) :1193-6.