SCH 900822
SCH 900822 is a potent and selective glucagon receptor (hGCGR) antagonist that blocks the binding of glucagon to its receptor, thereby reducing hepatic glycogenolysis and gluconeogenesis, thereby lowering blood glucose production. SCH 900822 can be used in the study of type 2 diabetes[1].
Product Specifications
CAS Number
1220894-09-6
UNSPSC
12352005
Target
GCGR
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sch-900822.html
Smiles
O=C(C1=CC=C([C@@H](CCC(C)(C)C)N([C@]2(N=C3C4=CC(Cl)=CC(Cl)=C4)CC[C@@H](C(C)(C)C)CC2)C3=O)C=C1)NCC5=NN=NN5
Molecular Formula
C34H43Cl2N7O2
Molecular Weight
652.66
References & Citations
[1]DeMong D, et al. The Discovery of N- ((2 H-Tetrazol-5-yl) methyl) -4- ((R) -1- ((5 r, 8 R) -8- (tert-butyl) -3- (3, 5-dichlorophenyl) -2-oxo-1, 4-diazaspiro [4.5] dec-3-en-1-yl) -4, 4-dimethylpentyl) benzamide (SCH 900822) : A Potent and Selective Glucagon Receptor Antagonist[J]. Journal of medicinal chemistry, 2014, 57 (6) : 2601-2610.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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