Rolipram (Standard)

Rolipram (Standard) is the analytical standard of Rolipram. This product is intended for research and analytical applications. Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Product Specifications

CAS Number

[61413-54-5]

Product Name Alternative

(R, S) -Rolipram (Standard) ; (±) -Rolipram (Standard) ; ZK 62711 (Standard)

UNSPSC

12352005

Target

Bacterial; HIV; Phosphodiesterase (PDE) ; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Others

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/rolipram-standard.html

Smiles

O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1

Molecular Formula

C16H21NO3

Molecular Weight

275.34

References & Citations

[1]MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr|[2]Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169 (7) :1525-36.|[3]Shalaby AM, et al. Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. J Pharmacol Pharmacother. 2012 Apr;3 (2) :132-7.